The Cross-Sectional Area of Paraspinal Muscles Predicts the Efficacy of Deep Drain Stimulation for Camptocormia
| Autor: | Waka Sakai, Keisuke Toyoda, Yuzo Yamakawa, Hidenori Matsuo, Akiko Nagaishi, Eisaku Sadakata, Shunya Nakane, Takayasu Fukudome, Eiichirou Urasaki |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Parkinson's disease Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation Paraspinal Muscles Stimulation Spinal Curvatures Muscular Atrophy Spinal 03 medical and health sciences Cellular and Molecular Neuroscience Camptocormia 0302 clinical medicine Lumbar Physical medicine and rehabilitation Subthalamic Nucleus medicine Humans Aged Retrospective Studies medicine.diagnostic_test Proprioception business.industry Magnetic resonance imaging Parkinson Disease Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Subthalamic nucleus 030104 developmental biology Treatment Outcome nervous system Spinal Cord Anesthesia Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of Parkinson's disease. 7(2) |
| ISSN: | 1877-718X |
| Popis: | Background Camptocormia, a disturbance of posture, is a well-described clinical feature of PD and other parkinsonian syndromes. Previous reports have shown that DBS of the subthalamic nucleus (STN) or globus pallidus internus is effective in treating camptocormia. However, the efficacy of DBS for camptocormia varies. Objective To determine a clinical marker for selecting an appropriate therapy for camptocormia, a disabling manifestation of Parkinson's disease (PD) that has a variable response to systemic and local therapies. Methods We obtained pre-operative lumbar magnetic resonance imaging of 14 consecutive PD patients with camptocormia who underwent subthalamic nucleus deep brain stimulation (STN-DBS) in this retrospective-designed study. Lumbar MRI was performed three to six months prior to the operation. We measured the cross-sectional area (CSA) and width of each participant's paraspinal muscles. Results Four (28.6%) patients were effective (EF), five (35.7%) were partially effective (PE), and five (35.7%) were non-effective (NE) to STN-DBS. The lumbar paraspinal CSA and width were significantly larger in the EF group than in the PE and NE groups. Conclusions The CSA of paraspinal muscles and erector spinae width can be good predictive markers for improving camptocormia in patients with PD after deep brain stimulation. |
| Databáze: | OpenAIRE |
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