The c-kit Receptor and Its Ligand Stem Cell Factor in Childhood Malignant Lymphoid Precursors
| Autor: | Annalisa Legitimo, Rita Consolini, Giuseppe Basso, M. G. Cocito, Pierantonio Macchia, R. Buffoni |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Stem Cell Factor
Leukemia CD117 Immunology Stem cell factor Cell Biology Biology Hematopoietic Stem Cells medicine.disease Proto-Oncogene Proteins c-kit Haematopoiesis Reference Values Virology Precursor cell biology.protein medicine Humans Cell Lineage Lymphocytes Progenitor cell Child Childhood Acute Lymphoblastic Leukemia |
| Zdroj: | Journal of Interferon & Cytokine Research. 19:981-987 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/107999099313172 |
| Popis: | The c-kit receptor (CD117) and its ligand stem cell factor (SCF) play an important role in the development, differentiation, and survival of normal and malignant hematopoietic cells. The aim of this work is to review the cellular distribution of this receptor and the effect of SCF on the hematopoietic system, particularly among lymphoid lineage, either in normal or malignant cell progenitors. We examined reports and results in the field and articles or abstracts published in journals covered by MEDLINE. Additionally, we evaluated CD117 expression on fresh blast cells of 376 newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL) that were referred to centers affiliated with the Italian Association for Pediatric Hematology and Oncology (AIEOP). In view of our data, approximately 11% of ALL are CD117 positive. In particular, this receptor can be expressed in 10% and 11.5% of T-lineage and B-lineage ALL, respectively. Its expression is associated with an intermediate/mature phenotype in T-lineage ALL, whereas in B-lineage ALL, the majority of the positive cases are classified as early B ALL. The effect of SCF on malignant hematopoiesis and its potential clinical uses are reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|