Prediction of HCV vertical transmission: what factors should be optimized using data mining computational analysis
| Autor: | Mohamed Alboraie, Mohamed Omar Amer, Akshaya Srikanth Bhagavathula, Altaher Salah, Abd Elrazek Abd Elrazek, Bahaa El-Hawary, Samy Saab |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Hepatitis C virus Hcv transmission Hepacivirus computer.software_genre medicine.disease_cause law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors law medicine Data Mining Humans Mass Screening Hcv prevalence Prospective Studies 030212 general & internal medicine Computational analysis Pregnancy Complications Infectious Hepatology business.industry Infant Newborn virus diseases Viral Load medicine.disease Hepatitis C Infectious Disease Transmission Vertical digestive system diseases Transmission (mechanics) RNA Viral Egypt Female 030211 gastroenterology & hepatology Data mining business computer Viral load |
| Zdroj: | Liver International. 37:529-533 |
| ISSN: | 1478-3223 |
| Popis: | Background & Aims Neonates born to hepatitis C virus (HCV)-positive mothers are usually not screened for HCV. Unscreened children may act as active sources for social HCV transmission, and factors contributing for vertical HCV transmitting still remained controversial and needed optimization. We aimed to investigate the factors contributing for vertical HCV transmission in Egypt; the highest HCV prevalence worldwide. Methods We prospectively followed the neonates born to HCV-positive mother in the child-bearing period, to identify mother-to-child transmission (MTCT) factors from January 2015 to March 2016. Data mining computational analysis was used to quantify the findings. Results Among 3000 randomized pregnant women, prevalence of HCV was 46/3000 (1.53%). HCV vertical transmission was identified in eight neonates (17.39%). Only high viral load identified at 975.000 IU was the predictor risk for MTCT. Conclusions Hepatitis C virus in pregnancy has substantial risk for vertical HCV transmission: High viral load in HCV-positive women increases the risk of HCV transmission to neonates. Screening pregnant women during early stage of pregnancy and optimizing the HCV viral load in HCV-positive women might prevent vertical HCV transmission to neonates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text