Behavioral Survey of Effects of Pulsed Radiofrequency on Neuropathic and Nociceptive Pain in Rats: Treatment Profile and Device Implantation
| Autor: | Yeong-Ray Wen, Shih-Ying Tsai, Kok-Yuen Ho, Yu-Chen Liu, Ping-Heng Tan, Lawrence Poree, Ren-Yu Huang |
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| Rok vydání: | 2021 |
| Předmět: |
SNi
Analgesic Nociceptive Pain Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Ganglia Spinal medicine Animals Nociception assay Pulsed radiofrequency business.industry General Medicine digestive system diseases Pulsed Radiofrequency Treatment Rats Disease Models Animal Anesthesiology and Pain Medicine Nociception Allodynia Neurology Anesthesia Neuropathic pain Neuralgia Intractable pain Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neuromodulation: Technology at the Neural Interface. 24:1458-1466 |
| ISSN: | 1094-7159 |
| DOI: | 10.1111/ner.13169 |
| Popis: | Objectives Pulsed radiofrequency (PRF) stimulation is widely used for intractable pain; however, there is no consensus on treatment protocols and appropriate types of pain. We compared effectiveness of bipolar and unipolar PRF on neuropathic or inflammatory pains, and of targets at the dorsal root ganglion (DRG) and sciatic nerve (SN). We also examined efficacy of repetitive PRF stimulations. This preclinical study could serve as an extensive survey before human trials. Materials Spare nerve injury (SNI)-induced neuropathic pain and complete Freund's adjuvant (CFA) injection-induced inflammatory pain were used. Behavioral responses were measured using von Frey test, acetone test, and Hargreave's test at preinjury and postinjury time points. In both models, we evaluated results of DRG stimulation with unipolar PRF (45 V) versus bipolar PRF (5 V), stimulation at DRG vs. SN, and repetitive stimulations. Results Both unipolar and bipolar PRFs reduced SNI- or CFA-induced pain for a similar duration. In the SNI model, PRF-DRG had a stronger effect on tactile pain than PRF-SN but lower effect on cold allodynia, whereas in the CFA model PRF-DRG and PRF-SN showed similar effects. Repetitive PRF stimulation, by open technique or implantation method, produced analogous effect by each stimulus, and no evident analgesic tolerance or neurological deficit was shown. Conclusions PRF temporarily attenuates neuropathic and inflammatory pain. Bipolar PRF generates significant analgesia with a much lower electrical power than unipolar PRF. Meanwhile, the minor variant effects between PRF-DRG and PRF-SN may indicate distinct mechanisms. The sustained-analgesia by repetitive treatments suggests implantation technique could be a promising choice. |
| Databáze: | OpenAIRE |
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