Genetic Polymorphisms of Vascular Endothelial Growth Factor and Angiopoietin 2 in Retinopathy of Prematurity
| Autor: | Ádám Vannay, Ilona Bányász, Barna Vásárhelyi, András Szabó, Beáta Szebeni, Tivadar Tulassay, Géza Bokodi, András Treszl |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Oncology congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Genotype genetic structures VEGF receptors Polymerase Chain Reaction Severity of Illness Index Angiopoietin-2 Cellular and Molecular Neuroscience chemistry.chemical_compound Gene Frequency Risk Factors Internal medicine medicine Humans Retinopathy of Prematurity Allele Alleles Retrospective Studies Polymorphism Genetic biology business.industry Angiopoietin 2 Carrier state Infant Newborn Retinopathy of prematurity DNA Prognosis medicine.disease eye diseases Sensory Systems Vascular endothelial growth factor Ophthalmology chemistry biology.protein Female sense organs business Follow-Up Studies |
| Zdroj: | Current Eye Research. 31:685-690 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.1080/02713680600801123 |
| Popis: | Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF(-2578) and Ang2(-35) polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF(-2578) and Ang2(-35) and risk of ROP in preterm infants. The prevalence of VEGF(-2578) "A" allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3). |
| Databáze: | OpenAIRE |
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