Prostanoid-induced contraction of the rabbit isolated uterus is mediated by FP receptors
| Autor: | Judith Senior, David F. Woodward, June Chen, Kay Marshall, Yang-Dar Yuan |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Prostaglandins F
Agonist medicine.medical_specialty Carbachol Physiology medicine.drug_class Receptors Prostaglandin Prostaglandin In Vitro Techniques Biochemistry Muscarinic agonist chemistry.chemical_compound Uterine Contraction Internal medicine Oxytocics medicine Animals Receptor Pharmacology Chemistry Uterus Prostanoid Cell Biology Smooth muscle contraction Endocrinology Prostaglandins F Synthetic cardiovascular system Prostaglandins lipids (amino acids peptides and proteins) Female Rabbits medicine.drug Signal Transduction |
| Zdroj: | Prostaglandinsother lipid mediators. 55(5-6) |
| ISSN: | 1098-8823 |
| Popis: | Natural and synthetic prostanoid agonists were used to study the prostanoid receptors involved in contraction of the mature, isolated uterus of virgin rabbits. The prostanoids elicited contractile responses with a rank order of potency of PGF2 alpha, fluprostenol > PGD2 > U-46,619 > PGE2 > carbaprostacyclin with mean EC50 (nM) values of 4, 6, 34, 550, 1318 and > 10,000, respectively. Carbachol, a muscarinic agonist given after the prostanoids to elicit a reference contraction, had a mean EC50 value of 1.1 microM. The results show that the mature rabbit uterus is most sensitive to prostaglandin FP agonists and, thus, can be defined pharmacologically as an FP receptor preparation. These findings may facilitative investigations into the possibility of different prostanoid receptor populations. In the absence of useful competitive FP receptor antagonists, agonist potency data is particularly useful in systems where cross-species comparisons and tissue-related factors are not involved. The potent activities of the FP agonists, PGF2 alpha and fluprostenol, in the isolated jugular vein and uterus of the rabbit suggest that these tissues may be useful for intra-species comparisons. |
| Databáze: | OpenAIRE |
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