Diffuse Axonal Injury Grade on Early MRI is Associated with Worse Outcome in Children with Moderate-Severe Traumatic Brain Injury
| Autor: | Sarah Lee, Scott Hamilton, Max Wintermark, Nicole Baier, Anna M Janas, Zachary D. Threlkeld, Bin Jiang, FeiFei Qin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Neurology Traumatic brain injury Pediatric neurocritical care Neuroimaging Diffuse Axonal Injury Critical Care and Intensive Care Medicine Internal medicine Brain Injuries Traumatic medicine Humans Glasgow Coma Scale Child Retrospective Studies Univariate analysis medicine.diagnostic_test business.industry Diffuse axonal injury Magnetic resonance imaging medicine.disease Prognosis Magnetic Resonance Imaging Secondary Outcome Measure Neurology (clinical) Neurosurgery business Original Work |
| Zdroj: | Neurocritical Care |
| ISSN: | 1556-0961 1541-6933 |
| Popis: | Background Traumatic brain injury (TBI) is the leading cause of death and disability in children, but effective tools for predicting outcome remain elusive. Although many pediatric patients receive early magnetic resonance imaging (MRI), data on its utility in prognostication are lacking. Diffuse axonal injury (DAI) is a hallmark of TBI detected on early MRI and was shown previously to improve prognostication in adult patients with TBI. In this exploratory study, we investigated whether DAI grade correlates with functional outcome and improves prognostic accuracy when combined with core clinical variables and computed tomography (CT) biomarkers in pediatric patients with moderate-severe TBI (msTBI). Methods Pediatric patients (≤ 19 years) who were admitted to two regional level one trauma centers with a diagnosis of msTBI (Glasgow Coma Scale [GCS] score |
| Databáze: | OpenAIRE |
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