Lassa virus glycoproteins: antigenic and immunogenic properties of synthetic peptides to GP1
| Autor: | A. T. Kozhich, Vadim T. Ivanov, I. S. Lukashevich, Leonid D. Tchikin, Kras'ko Ag, Anna B. Moshnikova, A. S. Vladyko |
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| Rok vydání: | 1990 |
| Předmět: |
Antigenicity
viruses Molecular Sequence Data Enzyme-Linked Immunosorbent Assay Peptide Biology medicine.disease_cause Epitope Virus Epitopes Viral Envelope Proteins Virology medicine Amino Acid Sequence Lassa virus Lassa fever Antigens Viral Glycoproteins chemistry.chemical_classification Immune Sera virus diseases General Medicine medicine.disease chemistry Polyclonal antibodies biology.protein Peptides Glycoprotein |
| Zdroj: | Archives of Virology. 115:133-137 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Synthetic peptides corresponding to predicted Lassa virus GP1 glycoprotein B-epitopes were used to study the antigenicity and immunogenicity of the protein. ELISA results showed that guinea pig polyclonal anti-Lassa virus serum bound effectively to peptides corresponding to amino acid residues 119-133 and 164-176 of the GP1 protein. Essentially it did not react to a peptide corresponding to GP1 amino acid residues 234-256. Sera obtained against peptides representing amino acid residues 119-133 and 164-176 reacted with inactivated purified Lassa virus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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