A Distinctive Lineage-Negative Cell Population Produces IL-17A in Cutaneous Squamous Cell Carcinoma
| Autor: | Brian R. Gastman, Jennifer S. Ko, Lillian D. Sun, Allison T. Vidimos, Shlomo A. Koyfman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cutaneous squamous cell carcinoma
Lineage (genetic) Skin Neoplasms medicine.medical_treatment Immunology Cell Population Biology medicine.disease_cause Proinflammatory cytokine T-Lymphocyte Subsets Virology medicine Humans Cell Lineage education education.field_of_study Interleukin-17 Interleukin Cell Biology Immunohistochemistry medicine.anatomical_structure Cytokine Cancer research Carcinoma Squamous Cell Cytokines Carcinogenesis Biomarkers |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 40(8) |
| ISSN: | 1557-7465 |
| Popis: | Interleukin (IL)-17A is a key proinflammatory cytokine indicated in multiple pathologies, including skin tumorigenesis. While IL-17A is a signature cytokine of Th17 cells, IL-17A is also produced by other cell types, including type 3 innate lymphoid cells (ILC3s) in the skin, particularly in patients with psoriasis. Interestingly, we detect CD45 |
| Databáze: | OpenAIRE |
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