Prolonged Cholestasis After Cyproheptadine-Induced Acute Hepatitis
| Autor: | Jean Geneve, Claude Degott, Dominique Pessayre, Jean-pierre Machayekhi, Dominique Larrey, Jean-Pierre Benhamou |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Cyproheptadine Imipramine Cholestasis Internal medicine medicine Humans Chlorpromazine Hepatitis Bile acid business.industry Hepatobiliary disease Gastroenterology medicine.disease Endocrinology Liver Acute Disease Toxicity Female Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Journal of Clinical Gastroenterology. 9:102-104 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-198702000-00026 |
| Popis: | We report a patient in whom cyproheptadine-induced hepatitis was followed by prolonged cholestasis marked by elevation of serum alkaline phosphatase levels, gammaglut-amyltransferase and bile acid levels, and disappearance of small bile ducts. Chlorpromazine and imipramine, which can induce a similar acute hepatitis followed by protracted cholestasis, have a close chemical structure (i.e., a tricyclic ring). We suggest that this structure might be involved in this type of hepatotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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