Association of the severity of vascular damage with discordance between the fractional flow reserve and non-hyperemic pressure ratios
| Autor: | Yuichi Sasaki, Kazuki Shiina, Hirofumi Tomiyama, Takamichi Takahashi, Ryosuke Ito, Hiroki Nakano, Masatsune Fujii, Ikki Komatsu, Naotaka Murata, Chisa Matsumoto, Jun Yamashita, Taishiro Chikamori |
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| Rok vydání: | 2022 |
| Předmět: |
Cardiac Catheterization
Coronary Stenosis Hyperemia Constriction Pathologic Middle Aged Pulse Wave Analysis Coronary Angiography Severity of Illness Index Coronary Vessels Fractional Flow Reserve Myocardial Predictive Value of Tests Humans Ankle Brachial Index Cardiology and Cardiovascular Medicine Aged |
| Zdroj: | Journal of cardiology. 81(2) |
| ISSN: | 1876-4738 |
| Popis: | While there is a discordance between fractional flow reserve (FFR) and non-hyperemic pressure ratios (NHPRs) in some cases, the mechanisms underlying these discordances have not yet been fully clarified. We examined whether vascular damage as assessed by measurement of the brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, or ankle brachial pressure index (ABI), a marker of atherosclerotic arterial stenosis, might be associated with their discordances.FFR and NHPRs were measured in 283 consecutive patients (69 ± 10 years old). Based on previously established cut-off values of the two markers (i.e. +/- = FFR ≤/0.80 or =NHPRs ≤/0.89), the study participants were divided into four groups (the + and - signs denoting "predictive of significant stenosis" and "not predictive of significant stenosis," respectively): the FFR+/NHPRs+ group (n = 124), FFR-/NHPRs+ group (n = 16), FFR+/NHPRs- group(n = 65), and FFR-/NHPRs- group (n = 78). The baPWV and ABI were also measured in all the participants, and values of2000 cm/s and ≥1.00 of the baPWV and ABI, respectively, were considered as representing relatively less advanced atherosclerotic systemic vascular damage.The prevalence of subjects with ABI ≥1.00 was higher in the FFR+/NHPRs- group than in the FFR-/NHPRs- group (p 0.05). When the study subjects were divided into 2 groups, namely, the FFR+/NHPRs- group and the combined group, the prevalence of ABI ≥1.00 and that of baPWV2000 cm/s were higher in the FFR+/NHPRs- group as compared with those in the combined group (p 0.05). The results of binary logistic regression analysis demonstrated that ABI ≥1.00 was associated with a significant odds ratio (2.34, p 0.05) for the FFR+/NHPRs- discordance.The FFR+/NHPRs- discordance appears to be observed in patients with relatively less advanced atherosclerotic systemic vascular damage. Thus, ABI ≥1.00 may be a marker of the presence of the FFR+/NHPRs- discordance. |
| Databáze: | OpenAIRE |
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