Randomised placebo-controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns
| Autor: | Yulin Chen, Xiaobing Fu, Zhiyong Sheng, Mingliang Zhang, Zhenrong Guo, Zuyao Shen, Junhe Xie |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Biopsy Basic fibroblast growth factor Placebo-controlled study Placebo Administration Cutaneous law.invention chemistry.chemical_compound Injury Severity Score Randomized controlled trial Double-Blind Method law Medicine Animals Humans Prospective Studies Adverse effect Child Aged Wound Healing business.industry Granulation tissue General Medicine Middle Aged Recombinant Proteins Surgery Clinical trial medicine.anatomical_structure chemistry Granulation Tissue Cattle Female Fibroblast Growth Factor 2 business Wound healing Burns |
| Zdroj: | Lancet (London, England). 352(9141) |
| ISSN: | 0140-6736 |
| Popis: | Summary Background Wound healing is a dynamic process that could be accelerated by growth factors. We investigated the effect of recombinant bovine basic fibroblast growth factor (rbFGF) on burn healing in a randomised placebo-controlled trial. Methods We recruited 600 patients with superficial or deep second-degree burns. Patients received 150 AU/cm 2 daily topical rbFGF (n=300) or placebo (n=300) plus vehicle. We assessed healing by photography, punch-biopsy, and clinical examination. Flndings All patients treated with rbFGF had faster granulation tissue formation and epidermal regeneration than those in the placebo group. Superficial and deep second-degree burns treated with rbFGF healed in a mean of 9·9 (SD 2·5) days and 17·0 (4·6) days, respectively, compared with 12·4 (2·7) and 21·2 (4·9) days (p=0·0008 and p=0·0003, respectively). No adverse effects were seen locally or systemically with rbFGF. Interpretation rbFGF effectively decreased healing time and improved healing quality. Clinical benefits would be shorter hospital stays and the patient's skin quickly becoming available for harvesting and grafting. |
| Databáze: | OpenAIRE |
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