Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling
| Autor: | Clive G. Bowsher, Craig A. McArdle, Thanh Pham, Kathryn Garner, George R. Pope, Christopher J. Caunt, Rebecca M. Perrett, Margaritis Voliotis, Krasimira Tsaneva-Atanasova |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Cell signaling medicine.medical_specialty GNRHR Cell Biology Gonadotropin-releasing hormone Biology C700 Biochemistry Cell biology 03 medical and health sciences 030104 developmental biology Endocrinology Internal medicine Negative feedback Homologous desensitization medicine Signal transduction Receptor Molecular Biology |
| Zdroj: | Journal of Biological Chemistry. 291:2246-2259 |
| ISSN: | 0021-9258 |
| DOI: | 10.1074/jbc.m115.686964 |
| Popis: | Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they transfer. Here we use single cell signaling measures to calculate mutual information as a measure of information transfer via gonadotropin-releasing hormone (GnRH) receptors (GnRHR) to extracellular signal-regulated kinase (ERK) or nuclear factor of activated T-cells (NFAT). This revealed mutual information values |
| Databáze: | OpenAIRE |
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