Autofluorescence imaging for recurrence detection in skin cancer postoperative scars
| Autor: | Emilija Vija Plorina, Janis Spigulis, Aleksandrs Derjabo, Mindaugas Tamošiūnas, Dmitrijs Bļizņuks, Marta Lange, Ilona Kuzmina |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Skin Neoplasms General Physics and Astronomy Scars Vector angle 01 natural sciences General Biochemistry Genetics and Molecular Biology 010309 optics Clinical study Cicatrix 0103 physical sciences medicine Humans General Materials Science Postoperative scars Postoperative monitoring Stage (cooking) business.industry Optical Imaging 010401 analytical chemistry General Engineering General Chemistry medicine.disease 0104 chemical sciences Autofluorescence Radiology Skin cancer medicine.symptom business |
| Zdroj: | Journal of Biophotonics. 13 |
| ISSN: | 1864-0648 1864-063X |
| DOI: | 10.1002/jbio.201900162 |
| Popis: | This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non-melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check-ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence-based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development. |
| Databáze: | OpenAIRE |
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