Successful use of N-acetyl cysteine and activated recombinant factor VII in fulminant hepatic failure and massive bleeding secondary to dengue hemorrhagic fever
| Autor: | Murugapillai K Ragunathan, Edirisooriya Maddumage Manoj, Gayan Ranasinghe |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
N-acetyl cysteine Dengue hemorrhagic fever Internal bleeding Case Report Gastroenterology Dengue fever law.invention chemistry.chemical_compound Fulminant hepatic failure law Internal medicine Massive bleeding Case fatality rate medicine Factor VII Activated recombinant factor VII business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 medicine.disease dengue Surgery chemistry Emergency Medicine Recombinant DNA medicine.symptom business fulminant hepatic failure |
| Zdroj: | Journal of Emergencies, Trauma and Shock, Vol 7, Iss 4, Pp 313-315 (2014) Journal of Emergencies, Trauma, and Shock |
| ISSN: | 0974-2700 |
| DOI: | 10.4103/0974-2700.142771 |
| Popis: | Consensus on management of complicated cases of dengue infection is evolving. Dengue hemorrhagic fever (DHF) occasionally progress to fulminant liver failure with high fatality rate. Inadvertent use of blood products to control massive bleeding in dengue shock syndrome may worsen fluid overload and subsequently the multi-organ dysfunction. We report a case of 37-years-old Sri Lankan man who developed fulminant liver failure and massive bleeding associated with DHF, subsequently recovered completely with supportive measures including administration of N-acetyl cysteine and activated recombinant factor VII. In conclusion, prevention of ischemic injury to liver and adoption of early aggressive supportive measures in complicated cases of dengue hemorrhagic fever is crucial for a favorable outcome. Indications for rFVIIa to arrest uncontrolled internal bleeding and use of NAC in non-acetaminophen-induced acute liver failure in complicated DHF are a platform for discussion. |
| Databáze: | OpenAIRE |
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