The Aryl Hydrocarbon Receptor Nuclear Translocator Gene Polymorphism in Patients With Recurrent Miscarriage
| Autor: | Robert M. Silver, Amy E. Sullivan, T. Flint Porter, D. Wane Branch, Antonio E. Frias, Leesa Nelson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Abortion Habitual Aryl hydrocarbon receptor nuclear translocator Genotype Immunology Biology law.invention Cohort Studies Gene Frequency law Recurrent miscarriage medicine Humans Immunology and Allergy Codon Gene Alleles Polymerase chain reaction Genetics Polymorphism Genetic Aryl Hydrocarbon Receptor Nuclear Translocator Embryogenesis Obstetrics and Gynecology medicine.disease Molecular biology Genotype frequency Amino Acid Substitution Reproductive Medicine Female Gene polymorphism |
| Zdroj: | American Journal of Reproductive Immunology. 55:51-53 |
| ISSN: | 1600-0897 8755-8920 |
| Popis: | Objective The human aryl hydrocarbon receptor nuclear translocator gene (ARNT) is crucial for embryonic development. Knockout of ARNT is embryonic lethal. We thus hypothesized that some cases of recurrent miscarriage (RM) may be due to a polymorphism in the ARNT gene. Methods Polymerase chain reaction was used to compare the gene frequencies of a polymorphism in codon 511 of the ARNT gene in 170 women with idiopathic RM and 105 controls. Results Using the Hardy–Weinberg equilibrium calculation, the predicted ARNT genotype frequencies for the N511/N511, N511/D511, and D511/D511 genotypes were 0, 2, and 167 respectively. The observed frequencies were 0, 2, and 168 (NS). The N/511/D511 genotype was detected in 1.2% of cases and 2.8% of controls, and the D511/D511genotype was detected in 98.8% of cases and 97.2% of controls (NS). Conclusions In our cohort of patients, the polymorphism in codon 511 of the ARNT gene is not associated with RM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|