Dimethoate-induced oxidative damage in erythrocytes of female adult rats
| Autor: | Nejla Soudani, Hanen Bouaziz, Ahmed Hakim, Najiba Zeghal, Afef Troudi, Ibtissem Ben Amara, Khaled Mounir Zeghal |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Health Toxicology and Mutagenesis medicine.medical_treatment Ascorbic Acid Toxicology Antioxidants Superoxide dismutase Eating Selenium chemistry.chemical_compound Internal medicine medicine Animals Vitamin E Dimethoate Rats Wistar chemistry.chemical_classification Analysis of Variance Vitamin C biology Chemistry Glutathione peroxidase Public Health Environmental and Occupational Health Glutathione Haemolysis Malondialdehyde Rats Oxidative Stress Endocrinology Biochemistry Dietary Supplements biology.protein Female Lipid Peroxidation |
| Zdroj: | Toxicology and Industrial Health. 28:222-237 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233711410909 |
| Popis: | Pesticide hazards have been accentuated by the sharp rise in their agricultural, industrial and domestic use. Acute exposure to pesticides can cause oxidative damage. Our study investigated the potential ability of selenium (Se) and/or vitamin E, used as nutritional supplements, to alleviate erythrocyte oxidative damage induced by dimethoate (DM), an organophosphate pesticide. Female Wistar rats were exposed to DM (0.2g/L−1of drinking water), DM + Se (0.5 mg/kg of diet), DM + vitamin E (100 mg/kg of diet), or DM + Se + vitamin E. Rats exposed to DM for 30 days showed an increase in malondialdehyde levels, superoxide dismutase and glutathione peroxidase activities in their erythocytes, while Na+,K+-ATPase and catalase activities, glutathione, non-protein thiol, vitamin E and vitamin C levels decreased. We also noted an increase in lactate dehydrogenase activity, marker of haemolysis and a decrease in acetylcholinesterase, the principal mode of organophosphorus action. Co-administration of Se or vitamin E to the diet of DM-treated rats ameliorated the biochemical parameters cited above. But the combined effect of Se and vitamin E was more powerful in antagonizing DM-induced oxidative stress. Therefore, our investigation revealed that both Se and vitamin E were useful elements in preventing DM-induced erythrocytes damage. |
| Databáze: | OpenAIRE |
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