Use of the New Proliferation Signal Inhibitor Everolimus in Renal Transplant Patients in Spain: Preliminary Results of the EVERODATA Registry
| Autor: | S. Zarraga, A. Alarcón, Isabel Beneyto, Ana Belén Benito Sánchez, J J. Plaza, Rafael Romero, Joan M. Diaz, Ana Fernández, Amado Andrés, P. Errasti, Jose-Vicente Torregrosa, José M. Morales, C. Cantarell, A. Morey, Manuel Rengel, Juan Carlos Ruiz |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Calcineurin Inhibitors Urology Renal function Nephrotoxicity Neoplasms medicine Humans Everolimus Registries Aged Retrospective Studies Antibacterial agent Sirolimus Transplantation Protein synthesis inhibitor business.industry Middle Aged Kidney Transplantation Surgery Calcineurin Clinical trial Spain Female business Cell Division Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation Proceedings. 39:2157-2159 |
| ISSN: | 0041-1345 |
| Popis: | Everolimus (Eve) has shown good efficacy and safety profiles in clinical trials in combination with low doses of cyclosporine but there is limited experience in other modes, especially with calcineurin inhibitor elimination. We developed a retrospective study to analyze its clinical use after approval in Europe in 2005. Herein we have presented the results of a series of 272 patients followed for the first 6 months after Eve introduction. In 93.8% of cases Eve was introduced after the first month posttransplantation (conversion use), and 6 months after introduction, the CNI had been eliminated in 75% of cases. The main indication for Eve introduction was the diagnosis of a malignant neoplasm (42%), whereas the combined indication of prevention and/or treatment of toxicity, especially nephrotoxicity, accounted for 46.3% of cases. Initial doses were low (1.37 mg/d), but were progressively increased up to 2 mg/d at 6 months. Renal function remained unchanged during the follow-up period, whereas proteinuria moderately increased. Only 5 cases (2%) of acute rejection episodes were observed with excellent patient and graft survivals at 6 months after conversion. Further analysis of this extensive series of patients with a longer follow-up is needed. |
| Databáze: | OpenAIRE |
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