Clinical features and outcomes of renal amyloidosis in Hong Kong

Autor:	Ronald Chi Chun Lin, Sze Kit Yuen, Siu Fai Cheung, Hon Lok Tang, Samuel Ka Shun Fung
Rok vydání:	2022
Předmět:	Proteinuria Nephrology Hypertension Diabetes Mellitus Hong Kong Humans Kidney Failure Chronic Immunoglobulin Light-chain Amyloidosis Amyloidosis General Medicine Kidney Glomerular Filtration Rate
Zdroj:	Nephrology. 27:869-876
ISSN:	1440-1797 1320-5358
DOI:	10.1111/nep.14089
Popis:	Early symptoms of primary (AL) amyloidosis are non-specific. Any delay in diagnosis and treatment results in poor outcome despite increasing treatment options. We aimed to determine baseline risk factors that identify patients with poor kidney outcomes and overall survivals.We recruited all patients aged 18 years or above with biopsy-proven renal amyloidosis between years 2000 and 2019 in three Hong Kong regional hospitals. Patients' clinical and pathological parameters, treatment response, kidney outcomes and overall survivals were recorded and analysed.Thirty-six cases of renal amyloidosis were recruited. Four cases were diagnosed to have multiple myeloma. Edema was the most common presenting symptom. The mean estimated glomerular filtration rate (eGFR) was 98.8 ml/min/1.73 mAmyloidosis, a rare disease with poor prognosis without treatment. Hypertension, diabetes mellitus, heavy proteinuria and low eGFR at diagnosis were associated with poor kidney outcome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243e06e29480abca10fafef8192ac06c https://doi.org/10.1111/nep.14089 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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