Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population

Autor: Aleksander Owczarek, Jan Kowalski, Malgorzata Kowalczyk, Wojciech Merk, Monika Paul-Samojedny, Piotr Choręza, Anna Fila-Danilow, Krzysztof Kucia, Renata Suchanek-Raif
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Suicide
Attempted
Linkage Disequilibrium
0302 clinical medicine
Genotype
Haplotype
HSPA1B
Schizophrenia
Paranoid
Middle Aged
Suicide
Neurology
Schizophrenia
Paranoid schizophrenia
Molecular Medicine
Female
Adult
medicine.medical_specialty
Adolescent
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
White People
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
HSP70 Heat-Shock Proteins
Polymorphism
Sex Distribution
Allele
Alleles
Genetic Association Studies
Aged
Genetic association
Original Paper
business.industry
medicine.disease
Minor allele frequency
030104 developmental biology
Haplotypes
Case-Control Studies
Poland
business
030217 neurology & neurosurgery
Zdroj: National Information Processing Institute
Neuromolecular Medicine
ISSN: 1559-1174
1535-1084
DOI: 10.1007/s12017-019-08575-1
Popis: This study aimed to find the potential association betweenHSPA1Bpolymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal behavior. A total of 901 unrelated Polish subjects of Caucasian origin (377 schizophrenia patients and 524 controls) were recruited. Four single-nucleotide polymorphisms (SNP) were genotyped using PCR–RFLP (rs539689, rs9281590) and TaqMan assays (rs263979, rs6547452). A strong tendency towards statistical significance (p = 0.051) was observed in rs539689 allele distribution between patients and controls in overall study subjects. After stratification according to gender, we found that rs539689 was significantly associated with schizophrenia in males, but not in females. The minor allele C had a protective effect in males [OR 0.73 (95% CI 0.61–0.88,p HSPA1Brs539689 polymorphism and attempted suicide in schizophrenic patients. The C/C genotype and C allele were protective against suicidal behavior in entire sample (p p p HSPA1Bgene may be involved in susceptibility to schizophrenia and clinical presentation of the disease in a sex-dependent manner, and may play a role in suicidal behavior in the Polish population of schizophrenic patients. Further independent analyses in different populations should be performed to clarify the role ofHSPA1Bin the pathogenesis of schizophrenia.
Databáze: OpenAIRE
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