Hipercoagulabilidad en fibrilación auricular y su relación con factores de riesgo para embolia sistémica
| Autor: | Albrecht Krämer Sch, Jaime Pereira, Mónica Acevedo B, Sandra Braun J, Ramón Corbalán H, Mª Teresa Lira C, Luis Pérez P, Daniel Springmüller, Jorge Tapia I, Isidro Huete, Gonzalo Sepúlveda |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Coagulation protein disorders business.industry Atrial fibrillation General Medicine medicine.disease Basal (phylogenetics) medicine.anatomical_structure Left atrial Internal medicine Diabetes mellitus Mitral valve Heart failure medicine Cardiology Coronary care unit cardiovascular diseases Thrombus business Embolism and thrombosis Arrhythmia circulatory and respiratory physiology |
| Zdroj: | Revista médica de Chile v.130 n.10 2002 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| Popis: | Background: Atrial fibrillation is associated to a high risk of systemic embolism and to hypercoagulability. Aim: To evaluate the activation of the coagulation cascade through determinations of the thrombin-antithrombin complex in patients with atrial fibrillation and to correlate this data with the clinical and echocardiographic risk factors for systemic embolism. Patients and Methods: In 53 patients with atrial fibrillation plasma levels of the thrombin-antithrombin complex were determined on admission to a coronary care unit and 30 days later. Using a univariate and multiple regression analysis, the association basal thrombin-antithrombin with the duration of the arrhythmia, age over 70 years, previous use of antiplatelet agents, history of hypertension, mitral valve disease, diabetes, heart failure, previous systemic embolism, left atrial diameter and the presence of spontaneous contrast echo or thrombus in the left atrial appendage, was studied. Results: Basal thrombin-antithrombin values were 40.1±69 mg/L (Median 8.34 [3.0-47.5]) compared to 2.7±3.3 mg/L in healthy controls (p |
| Databáze: | OpenAIRE |
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