Basal ganglia and ventricle volume in first-episode psychosis. A family and clinical study
| Autor: | Teresa Cabada, Victor Peralta, Manuel J. Cuesta, Lucía Moreno-Izco, Ana M. Sánchez-Torres, Ruth Lorente-Omeñaca, Jose M. López-Ilundain, Pablo Lecumberri, Marisol Gómez, María Ribeiro |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Adolescent Thalamus Neuroscience (miscellaneous) Basal Ganglia Young Adult 03 medical and health sciences 0302 clinical medicine Lateral Ventricles Internal medicine Basal ganglia medicine Humans Radiology Nuclear Medicine and imaging Third Ventricle Brain Ventricle Third ventricle Siblings Putamen medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Ventricle Laterality Cardiology Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research: Neuroimaging. 269:90-96 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2017.09.010 |
| Popis: | Patients with first-episode psychosis (FEP) exhibit considerable heterogeneity in subcortical brain volumes. We sought to compare ventricle and basal ganglia volumes in FEP patients (n = 50) with those in unaffected relatives (n = 21) and healthy controls (n = 24). Participants were assessed with a semistructured interview and underwent structural magnetic resonance imaging (MRI). Patients had significantly larger left lateral, right lateral and third ventricle volumes than their siblings and larger third ventricle volumes than controls. Additionally, they showed a trend toward significance by having larger right caudate nuclei than controls. Moreover, FEP patients showed lower caudate and putamen laterality indexes (leftward shifts) than healthy controls but not regarding their siblings. Besides, negative dimension was directly associated with lateral and third ventricle volumes and positive dimension with thalamus and ventral diencephalon nuclei. Our findings added evidence to the associations between early enlargement of brain ventricles and negative symptoms, and between early enlargement of thalamic and ventral-diencephalon nuclei and positive symptoms. Moreover, the cumulative exposition to antipsychotics in FEP patients might be related to enlargement of certain subcortical structures, such as the right nucleus accumbens and third ventricle. |
| Databáze: | OpenAIRE |
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