Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection
| Autor: | Siamon Gordon, Padraic G. Fallon, Rachel Vacher, Cecile Fremond, Virginie Vasseur, Yury V. Shebzukhov, Nathalie Court, Vladimir Yeremeev, Valérie F. J. Quesniaux, Sergei A. Nedospasov, Isabelle Maillet, Bernhard Ryffel, Hiroshi Suzuki |
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| Přispěvatelé: | Immunologie et Embryologie Moléculaires (IEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
CD36 Antigens
Chemokine MESH: Mycobacterium tuberculosis MESH: Interferon-gamma MESH: Mice Transgenic Immunology Mice Transgenic Immune receptor Mycobacterium tuberculosis MESH: Receptors Pattern Recognition Interferon-gamma Mice 03 medical and health sciences 0302 clinical medicine MESH: Reverse Transcriptase Polymerase Chain Reaction Animals Tuberculosis Immunology and Allergy MESH: Microscopy Confocal Lectins C-Type MESH: Animals MESH: Tuberculosis MESH: Receptors Scavenger Receptor MESH: Mice 030304 developmental biology Receptors Scavenger 0303 health sciences Microscopy Confocal Innate immune system biology Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha MESH: Antigens CD36 Pattern recognition receptor MESH: Interleukin-1 biology.organism_classification 3. Good health Macrophage receptor with collagenous structure Receptors Pattern Recognition MESH: Tumor Necrosis Factor-alpha biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Mannose receptor MESH: Lectins C-Type Interleukin-1 030215 immunology |
| Zdroj: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 184 (12), pp.7057-70. ⟨10.4049/jimmunol.1000164⟩ |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.1000164⟩ |
| Popis: | Mycobacterium tuberculosis is recognized by multiple pattern recognition receptors involved in innate immune defense, but their direct role in tuberculosis pathogenesis remains unknown. Beyond TLRs, scavenger receptors (SRs) and C-type lectins may play a crucial role in the sensing and signaling of pathogen motifs, as well as contribute to M. tuberculosis immune evasion. In this study, we addressed the relative role and potential redundancy of these receptors in the host response and resistance to M. tuberculosis infection using mice deficient for representative SR, C-type lectin receptor, or seven transmembrane receptor families. We show that a single deficiency in the class A SR, macrophage receptor with collagenous structure, CD36, mannose receptor, specific ICAM-3 grabbing nonintegrin-related, or F4/80 did not impair the host resistance to acute or chronic M. tuberculosis infection in terms of survival, control of bacterial clearance, lung inflammation, granuloma formation, and cytokine and chemokine expression. Double deficiency for the SRs class A SR types I and II plus CD36 or for the C-type lectins mannose receptor plus specific ICAM-3 grabbing nonintegrin-related had a limited effect on macrophage uptake of mycobacteria and TNF response and on the long-term control of M. tuberculosis infection. By contrast, mice deficient in the TNF, IL-1, or IFN-γ pathway were unable to control acute M. tuberculosis infection. In conclusion, we document a functional redundancy in the pattern recognition receptors, which might cooperate in a coordinated response to sustain the full immune control of M. tuberculosis infection, in sharp contrast with the nonredundant, essential role of the TNF, IL-1, or IFN-γ pathway for host resistance to M. tuberculosis. |
| Databáze: | OpenAIRE |
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