Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
| Autor: | Kotaro Hattori, Naoji Amano, Sumiko Yoshida, Kunimasa Arima, Chisato Wakabayashi, Hiroshi Kunugi, Toshiya Teraishi, Teruhiko Higuchi, Daimei Sasayama, Hiroaki Hori, Miho Ota |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty behavioral disciplines and activities Gastroenterology Statistics Nonparametric Cerebrospinal fluid Internal medicine mental disorders medicine Humans In patient Interleukin 6 Biological Psychiatry Depression (differential diagnoses) Depressive Disorder Major biology Interleukin-6 Middle Aged medicine.disease Pathophysiology Peripheral Psychiatry and Mental health Schizophrenia Anesthesia biology.protein Major depressive disorder Female Psychology |
| Zdroj: | JOURNAL OF PSYCHIATRIC RESEARCH. 47(3):401-406 |
| Popis: | 信州大学博士（医学）・学位論文・平成25年3月31日授与（甲第944号）・篠山 大明 Elevated peripheral levels of interleukin-6 (IL-6) are common findings in schizophrenia and depression. However, previous studies that measured cerebrospinal fluid (CSF) IL-6 levels in these disorders reported controversial results. The present study examined whether CSF IL-6 levels are altered in patients with schizophrenia and those with depression. Lumbar punctures were performed in 32 patients with schizophrenia, 30 with major depressive disorder (MDD), and 35 healthy controls. Serum samples were simultaneously collected from all subjects in the patient groups and from 32 of the control group. CSF and serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Both the patients with schizophrenia and MDD had significantly higher CSF IL-6 levels compared to the controls (schizophrenia: P = 0.0027; MDD: P = 0.012). IL-6 levels were significantly higher in the CSF than in the serum. No significant correlation was observed between CSF and serum IL-6 levels. The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded. (C) 2012 Elsevier Ltd. All rights reserved. Article JOURNAL OF PSYCHIATRIC RESEARCH. 47(3):401-406 (2013) |
| Databáze: | OpenAIRE |
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