Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis
| Autor: | Jenna Griffiths, Nicole L. Pratt, Tsugumichi Sato, Tong Tong Wang, Esther W. Chan, Byung Joo Park, Tomomi Kimura, Michio Kimura, Xue Mei Jin, Tuan Anh Nguyen, Yea Huei Kao Yang, Edward Chia Cheng Lai, Ian C. K. Wong, Ju-Young Shin, Nobuhiro Ooba, Nam Kyong Choi, Joongyub Lee, Kenneth K.C. Man, Elizabeth E. Roughead, Kiyoshi Kubota |
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| Přispěvatelé: | Roughead, Elizabeth E, Chan, Esther W, Choi, Nam-Kyong, Griffiths, Jenna, Jin, Xui-Mei, Lee, Joongyub, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Man, Kenneth KC, Nguyen, Tuan Anh, Ooba, Nobuhiro, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Wang, TongTong, Wong, Ian CK, Yang, Yea-Huei Kao, Pratt, Nicole L |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Asia genetic structures Databases Factual Population sequence symmetry analysis adverse event Total population 03 medical and health sciences 0302 clinical medicine Vancomycin medicine Humans Pharmacology (medical) 030212 general & internal medicine education National data Oral vancomycin Sequence (medicine) Aged education.field_of_study business.industry Clostridioides difficile Proton Pump Inhibitors General Medicine Clostridium difficile clostridium difficile Clostridium difficile infections Surgery Anti-Bacterial Agents Clostridium Infections 030211 gastroenterology & hepatology proton pump inhibitors business Demography Multi country |
| Popis: | Objective: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest. Results: 54,957 patients were included. Positive associations were observed in Australia; adjusted sequence ratio (ASR) 2.48 (95% CI 1.90, 3.12), Korea ASR 2.15 (95%CI 2.11, 2.19), Canada ASR 1.45 (95% CI 1.16, 1.79), Japan hospital dataset ASR 3.21 (95%CI 2.12, 4.55) and Japan worker insurance dataset ASR 5.40 (95% CI 2.73, 8.75). The pooled result was ASR 2.40 (95%CI 1.88, 3.05) and 3.16 (95%CI 1.95, 5.10) when limited to Japan, Korean and Taiwan. Results did not vary by individual PPI. The temporal analysis showed effects within the first two weeks of PPI initiation. Conclusion: Our study confirms the association between PPI initiation and C. difficile infections across countries in the Asia-Pacific region. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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