Pre-exposure of adolescent mice to morphine results in stronger sensitization and reinstatement of conditioned place preference than pre-exposure to hydrocodone
| Autor: | Shoshana Eitan, Paul J. Wellman, Caitlin A Madison |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
media_common.quotation_subject Conditioning Classical Pharmacology Extinction Psychological Mice 03 medical and health sciences 0302 clinical medicine Recurrence medicine Animals Pharmacology (medical) Hydrocodone Sensitization media_common Dose-Response Relationship Drug Morphine business.industry Addiction Age Factors Opioid use disorder Opioid-Related Disorders medicine.disease Conditioned place preference 030227 psychiatry Analgesics Opioid Mice Inbred C57BL Psychiatry and Mental health medicine.anatomical_structure business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 34:771-777 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881120926675 |
| Popis: | Background: Opioids are commonly prescribed to treat moderate-to-severe pain. However, their use can trigger the development of opioid use disorder. A major problem in treating opioid use disorder remains the high rate of relapse. Aim: The purpose of this study was to determine whether there are differences among opioids in their ability to trigger relapse after pre-exposure during adolescence. Methods: On postnatal day 33, mice were examined for the acute locomotor response to saline, morphine, or hydrocodone (5 mg/kg). They were administered with the corresponding opioid or saline during postnatal days 34–38 (20 mg/kg) and 40–44 (40 mg/kg). On postnatal day 45, they were recorded for the development of locomotor sensitization (5 mg/kg). Starting on postnatal day 55, mice were examined for the acquisition (1, 5, 10, 20, and 40 mg/kg), extinction, and drug-induced reinstatement (1, 2.5, and 5 mg/kg) of conditioned place preference. Results: There were no significant differences in the acute locomotor response to morphine and hydrocodone. Morphine induced significantly stronger locomotor sensitization as compared to hydrocodone. Pre-exposure to morphine, but not hydrocodone, sensitized the acquisition of conditioned place preference. There were no significant differences in extinction rates. Mice pre-exposed to morphine reinstate conditioned place preference after priming with a 1 mg/kg dose. In contrast, higher priming doses were required for reinstatement in all other experimental groups. Conclusions: Adolescent mice administered with morphine develop greater sensitization to its effects and subsequently reinstate conditioned place preference more readily than mice administered with hydrocodone. This suggests higher risk for relapse after pre-exposure to morphine during adolescence as compared to hydrocodone. |
| Databáze: | OpenAIRE |
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