Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis
| Autor: | Ewa Kurys-Denis, Anna Błażewicz, Lech Panasiuk, Jarosław Sak, Jarosław Niedziałek, Paweł Kiciński, Andrzej Prystupa, Dorota Luchowska-Kocot |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcoholic liver disease Cirrhosis Bilirubin liver cirrhosis chemistry.chemical_element Zinc lcsh:Agriculture 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine fibroblast growth factor-19 Fibrosis Liver Cirrhosis Alcoholic Internal medicine Parenchyma medicine Humans selenium Waste Management and Disposal Ecology Evolution Behavior and Systematics lcsh:Environmental sciences Aged lcsh:GE1-350 endoglin alcohol zinc Public Health Environmental and Occupational Health lcsh:S Endoglin Middle Aged medicine.disease Fibroblast Growth Factors Endocrinology chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Angiogenesis Inducing Agents Female Selenium |
| Zdroj: | Annals of Agricultural and Environmental Medicine, Vol 24, Iss 3, Pp 544-548 (2017) |
| ISSN: | 1898-2263 1232-1966 |
| Popis: | Introduction and objective Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine the relationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogenic cytokines (FGF-19, ENG). Material and methods The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatography with UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurements of selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorption spectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples. Results Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|