Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine
| Autor: | M. D. Hussain, Paul L. Chazot, Abdelkader Ennaceur, Rushdie Abuhamdah |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_treatment Experimental and Cognitive Psychology Anxiety Receptors N-Methyl-D-Aspartate C57bl6 j 03 medical and health sciences Behavioral Neuroscience Random Allocation 0302 clinical medicine medicine Avoidance Learning Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Habituation Habituation Psychophysiologic Maze Learning Saline Sensitization Spatial Memory Psychological Tests Radial arm maze sub_pharmacyandpharmacology 05 social sciences Recognition Psychology Resilience Psychological Dizocilpine Mice Inbred C57BL medicine.anatomical_structure Anesthesia Models Animal sub_neuropsychology Exploratory Behavior NMDA receptor medicine.symptom Dizocilpine Maleate Psychology Excitatory Amino Acid Antagonists 030217 neurology & neurosurgery sub_biomedicalsciences medicine.drug Personality |
| Zdroj: | Physiology & behavior, 2016, Vol.164(Part A), pp.353-360 [Peer Reviewed Journal] |
| ISSN: | 0031-9384 |
| Popis: | Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our previous study indicates that MK-801 (dizocilpine), NMDA antagonist, increased anxiety and prevented the acquisition of a spatial memory task. Here, we examined whether MK-801 will produce anxiety in mice that were familiar with the test environment.\ud \ud Male C57BL/6J mice were exposed, one session a day for 7 days, to a 3D maze, which consisted of nine arms attached to upward inclined bridges radiating from a nonagonal platform. In this maze, high anxiety mice avoid the arms in the first sessions. One group of mice received saline (SAL) while a second group received MK-801 (MKD1), both on day one. A third group received saline in the first 3 sessions, and MK 801 in subsequent sessions (MKD4). Saline and MK-801 (0.1 mg/kg) were administered intraperitoneally 30 min before the test.\ud \ud MKD4 mice demonstrated an increase in bridge and arm visits, and reached arm/bridge entries ratio close to 1 in session 5. SAL mice also crossed frequently onto the arms, and reached a comparable ratio, but this was achieved with a lower number of arm visits. MKD1 mice demonstrated a reduced number of arm visits in each session compared to SAL and MKD4 mice.\ud \ud Dizocilpine produced anxiety in mice treated from day 1 of the test, but not in those treated from day 4. It also impaired habituation in animals familiar with the test environment; it produced sustained non-habituating hyperactivity. |
| Databáze: | OpenAIRE |
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