The effect of short‐term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

Autor: Sophie J Edwards, Matthew S. Brook, Leigh Breen, Konstantinos N. Manolopoulos, Nima Gharahdaghi, Alison Rushton, Paul T. Morgan, Andrew Philp, Yasir S Elhassan, Kenneth Smith, Philip J. Atherton, Benoit Smeuninx, Elizabeth Sapey
Rok vydání: 2020
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 1, Pp 52-69 (2021)
Journal of Cachexia, Sarcopenia and Muscle
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.12661
Popis: Background Poor recovery from periods of disuse accelerates age‐related muscle loss, predisposing individuals to the development of secondary adverse health outcomes. Exercise prior to disuse (prehabilitation) may prevent muscle deterioration during subsequent unloading. The present study aimed to investigate the effect of short‐term resistance exercise training (RET) prehabilitation on muscle morphology and regulatory mechanisms during 5 days of bed rest in older men. Methods Ten healthy older men aged 65–80 years underwent four bouts of high‐volume unilateral leg RET over 7 days prior to 5 days of inpatient bed rest. Physical activity and step‐count were monitored over the course of RET prehabilitation and bed rest, whilst dietary intake was recorded throughout. Prior to and following bed rest, quadriceps cross‐sectional area (CSA), and hormone/lipid profiles were determined. Serial muscle biopsies and dual‐stable isotope tracers were used to determine integrated myofibrillar protein synthesis (iMyoPS) over RET prehabilitation and bed rest phases, and acute postabsorptive and postprandial myofibrillar protein synthesis (aMyoPS) rates at the end of bed rest. Results During bed rest, daily step‐count and light and moderate physical activity time decreased, whilst sedentary time increased when compared with habitual levels (P
Databáze: OpenAIRE
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