Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats
| Autor: | Lilia Kadeche, Mohamed Salah Boulakoud, Mahfoud Messarah, Mongi Saoudi, Amel Boumendjel, Abdelfattah El Feki |
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| Rok vydání: | 2012 |
| Předmět: |
Male
inorganic chemicals Antioxidant Thiobarbituric acid Health Toxicology and Mutagenesis medicine.medical_treatment chemistry.chemical_element Green tea extract Pharmacology Kidney Protective Agents Toxicology medicine.disease_cause Thiobarbituric Acid Reactive Substances Camellia sinensis Arsenic Lipid peroxidation chemistry.chemical_compound Testis medicine Animals Aspartate Aminotransferases Rats Wistar Analysis of Variance Arsenic toxicity Plant Extracts Public Health Environmental and Occupational Health Alanine Transaminase Blood Proteins Organ Size Rats Oxidative Stress Liver Biochemistry chemistry Toxicity Erythrocyte Count Lipid Peroxidation Oxidative stress |
| Zdroj: | Toxicology and Industrial Health. 29:349-359 |
| ISSN: | 1477-0393 0748-2337 |
| Popis: | The present work was undertaken to evaluate the protective effect of an aqueous extract of green tea (GT, Camellia sinensis) leaves against arsenic (NaAsO2)-induced biochemical toxicity and lipid peroxidation production in experimental rats. The treatment with arsenic exhibited a significant increase in some serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, albumin, bilirubin, cholesterol, urea and creatinine). But the co-administration of GT has increased the level of plasmatic concentration of biochemical parameters. Exposure of rats to arsenic caused also a significant increase in liver, kidney and testicular thiobarbituric acid reactive substances compared to control. However, the co-administration of GT was effective in reducing its level. To conclude, our data suggest that arsenic exposure enhanced an oxidative stress by disturbing the tissue antioxidant defense system, but the GT co-administration alleviates the toxicity induced by arsenic exposure. |
| Databáze: | OpenAIRE |
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