Intermediary metabolism in the Swarm rat chondrosarcoma chondrocyte
| Autor: | C A Spencer, R M Mason, T N Palmer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Glutamine
Chondrosarcoma Oxidative phosphorylation Biochemistry Chondrocyte Culture Techniques medicine Animals Glycolysis Molecular Biology Glycosaminoglycans biology Adenine Nucleotides Cell Biology Metabolism medicine.disease Rats Cartilage Glucose medicine.anatomical_structure Proteoglycan biology.protein Intracellular Research Article |
| Zdroj: | Biochemical Journal. 265:911-914 |
| ISSN: | 1470-8728 0264-6021 |
| Popis: | The rat chondrosarcoma chondrocyte has the dual capacity to metabolize glucose (mainly via glycolysis) and glutamine (via an oxidative pathway). Glutamine metabolism, unlike that of glucose, is unable to sustain intracellular ATP concentrations. Glutamine consumption by the chondrosarcoma chondrocyte, however, is significantly in excess of its utilization as an amide-group donor in hexosamine synthesis, implying a novel and major role in cell metabolism. |
| Databáze: | OpenAIRE |
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