High incidence of diminished ovarian reserve in young unexplained recurrent pregnancy loss patients
| Autor: | Lorna A. Marshall, L. Hickok, Julie D. Lamb, Kaitlyn Wald, Lora K. Shahine |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Anti-Mullerian Hormone medicine.medical_specialty Abortion Habitual Endocrinology Diabetes and Metabolism Aneuploidy Diminished ovarian reserve 030209 endocrinology & metabolism Miscarriage Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy medicine Humans Prospective Studies Ovarian Reserve 030219 obstetrics & reproductive medicine Obstetrics business.industry Incidence Uterus Age Factors Obstetrics and Gynecology medicine.disease Thyroid Diseases Urogenital Abnormalities Antibodies Antiphospholipid Female High incidence Follicle Stimulating Hormone business Infertility Female |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 36(12) |
| ISSN: | 1473-0766 |
| Popis: | Recurrent pregnancy loss (RPL) is a clinically challenging scenario for patients and providers since an evidence-based approach to evaluation results in no explanation at least 50% of the time. The most common cause of first trimester clinical miscarriage is chromosome imbalance in the embryo or aneuploidy and the incidence of aneuploidy increases with age and diminished ovarian reserve (DOR). Currently, no professional societies recommend ovarian reserve testing in RPL patients, but some research shows a higher rate of DOR in miscarriage patients. The objective of this study was to evaluate the prevalence of DOR in unexplained vs. explained RPL patients. A prospective cohort study was completed, including 264 patients with recurrent pregnancy loss, 87 with an identifiable cause and 177 patients unexplained. A higher percentage of patients with unexplained RPL had DOR compared to patients with a known cause for RPL (48% vs 29% |
| Databáze: | OpenAIRE |
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