Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells

Autor:	G. K. Gerasimova, Yu. V. Rodionova, Z. S. Smirnova, E. S. Gershtein, A. S. Khalanskii
Předmět:	business.industry Therapeutic effect Brain tumor General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Glucocorticoid receptor medicine Cytotoxic T cell business Glucocorticoid Anaplastic astrocytoma medicine.drug Glioblastoma Hormone
Zdroj:	Scopus-Elsevier
Popis:	Potent therapeutic effect of hormonal cytostatic cortifen on intracranial brain tumors in rats was demonstrated. The effect was seen after single cortifen course in glioblastoma expressing glucocorticoid receptors and after two courses in glucocorticoid receptor-negative anaplastic astrocytoma. These findings confirmed the concept that selectivity of antitumor drugs can be improved when hormones are used as the carries of cytotoxic groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242e503a201179cf778737a75f19e154 http://www.scopus.com/inward/record.url?eid=2-s2.0-26944454872&partnerID=MN8TOARS Zobrazit plný text záznamu