Murine Leukemia Virus Recombinants That Use Phosphate Transporters for Cell Entry Induce Similar Spongiform Encephalomyelopathies in Newborn Mice
| Autor: | Carsten Münk, Carol Stocking, Jürgen Löhler, Silke Thomsen |
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| Rok vydání: | 1998 |
| Předmět: |
Time Factors
Ataxia Transfection Virus Cell Line Prion Diseases Mice Virology Murine leukemia virus Virus latency medicine Animals Receptor Recombination Genetic biology Brain Membrane Proteins 3T3 Cells Phosphate-Binding Proteins biology.organism_classification medicine.disease Virus Latency Leukemia Animals Newborn Spinal Cord nervous system Cell culture Receptors Virus Moloney murine leukemia virus medicine.symptom Carrier Proteins |
| Zdroj: | Virology. 252:318-323 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.1998.9476 |
| Popis: | Amphotropic Moloney-murine leukemia virus recombinants (Mo-AmphoV) induce a severe spongiform encephalomyelopathy in newborn mice. We show here that a coisogenic recombinant with a 10A1-MuLV host range (Mo-10A1V) also induces a neurodegenerative disease, clinically characterized by mild tremor and ataxia. Spongiform lesions are most severe in the metencephalon and mesencephalon but extend into the prosencephalon and spinal cord. Significantly, the quality of histopathology was indistinguishable between Mo-AmphoV and Mo-10A1V, probably reflecting a final common pathogenic pathway. Common receptor use thus may be an important determinant in the pathogenicity of these viruses. These results have implications for the clinical use of retroviral pseudotypes that use phosphate transporters for cell entry. |
| Databáze: | OpenAIRE |
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