| Autor: |
Nikolaos Dagres, Glen P. Martin, Zoher Kapacee, Xavier Jouven, Valentina Kutyifa, Serge Boveda, Juhani Junttila, Christian Sticherling, Katherine C. Wu, Rik Willems, Antti M. Kiviniemi, Frieder Braunschweig, Georg Schmidt, Jiri Jarkovsky, Jens Brock Johansen, Mahmoud Suleiman, Alireza Sepehri Shamloo, Artur Akbarov, Laura Fusini, Stephanie Ng, Christian de Chillou, Francisco Leyva, Dick L. Willems, Kevin Kris Warnakula Olesen, Radosław Lenarczyk, Andrea Manca, Youssef Taleb, Arthur A.M. Wilde, Eloi Marijon, Milos Taborsky, Jens Cosedis Nielsen, Niels Peek, Julie Pester, Markus Zabel, Gerhard Hindricks, Gordon F. Tomaselli, Petra Barthel, Chris P Gale, Nancy R. Cook, Golnoosh Motamedi-Ghahfarokhi, Jonas Faxén, Le Mai Parkes, Peter J. Schwartz, Michael Maeng, Christine M. Albert, Gianluca Pontone, Tim Friede, Enrico Longato, Jacob Tflt-Hansen, Manickavasagar Vinayagamoorthy, Daniel Lee, Jan G.P. Tijssen, Ursula Marschall, Tom E Verstraelen, Christopher A. Miller, Hanno L. Tan, Marcus Eng Hock Ong, Petra J. M. Elders, Jill Leigh, Daniel Sprague, Thomas Olsen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
medRxiv |
| Popis: |
IntroductionSudden cardiac death (SCD) is the leading cause of death in patients with myocardial infarction (MI) and can be prevented by the implantable cardioverter defibrillator (ICD). Currently, risk stratification for SCD and decision on ICD implantation are based solely on impaired left ventricular ejection fraction (LVEF). However, this strategy leads to over- and under-treatment of patients because LVEF alone is insufficient for accurate assessment of prognosis. Thus, there is a need for better risk stratification. This is the study protocol for developing and validating a prediction model for risk of SCD in patients with prior MI.Methods and AnalysisThe EU funded PROFID project will analyse 23 datasets from Europe, Israel and the US (∼225,000 observations). The datasets include patients with prior MI or ischemic cardiomyopathy with reduced LVEFEthics and disseminationLocal ethical approval was obtained. The final model will be disseminated through scientific publications and a web-calculator. Statistical code will be published through open-source repositories. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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