Treating humoral rejection after cardiac transplantation
| Autor: | Jef Verheyen, Viviane M. Conraads, Karin Janssen van Doorn, Tom Vermeulen, Christiaan J. Vrints |
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| Rok vydání: | 2011 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Combination therapy business.industry medicine.medical_treatment Immunoglobulins General Medicine Plasmapheresis Middle Aged Complete resolution Combined Modality Therapy Surgery Immunity Humoral Transplantation Treatment modality Female patient medicine Heart Transplantation Humans Female Human medicine Cardiology and Cardiovascular Medicine business Diffi cult |
| Zdroj: | Acta cardiologica |
| ISSN: | 0001-5385 |
| Popis: | Whereas effective strategies are available to treat acute cellular cardiac rejection, humoral rejection, also called vascular or antibody-mediated rejection, is more difficult to manage. Antibody-mediated (non-cellular) rejections (AMR) are rare and few successfully treated cases have been described in the literature. We report on a female patient, diagnosed with humoral rejection, leading to severe ventricular dysfunction and haemodynamic compromise, two months after transplantation. The patient received a combination therapy, consisting of plasmapheresis and immunoglobulins, which resulted in complete resolution of immunohistochemical signs of AMR. In this report, we will overview AMR and discuss several treatment modalities. |
| Databáze: | OpenAIRE |
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