Adiponectin deficiency-induced diabetes increases TNFα and FFA via downregulation of PPARα
Autor: | Motohito Goto, Takahiro Kagawa, Toshio Akimoto, Hayato Abe, Riichi Takahashi, Emika Sugiura, Haruo Hashimoto, Hiroshi Suemizu, Yamamoto Masafumi |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Down-Regulation Peroxisome proliferator-activated receptor Fatty Acids Nonesterified PPARα Impaired glucose tolerance Mice 03 medical and health sciences 0302 clinical medicine Insulin resistance Downregulation and upregulation Laboratory Animal Science Internal medicine Glucose Intolerance Diabetes Mellitus medicine Animals Insulin PPAR alpha Mice Knockout chemistry.chemical_classification Glucose tolerance test adiponectin diabetes General Veterinary medicine.diagnostic_test Adiponectin Tumor Necrosis Factor-alpha Chemistry Insulin tolerance test Note medicine.disease 030104 developmental biology Endocrinology Gene Expression Regulation 030220 oncology & carcinogenesis |
Zdroj: | The Journal of Veterinary Medical Science |
ISSN: | 1347-7439 0916-7250 |
Popis: | Expression of peroxisome proliferator-activated receptor (PPAR) α was investigated in adiponectin knockout mice to elucidate the relationship between PPARα and adiponectin deficiency-induced diabetes. Adiponectin knockout (Adp−/−) mice were generated by gene targeting. Glucose tolerance test (GTT), insulin tolerance test (ITT), and organ sampling were performed in Adp−/− mice at the age of 10 weeks. PPARα, insulin, triglyceride, free fatty acid (FFA), and tumor necrosis factor α (TNFα) were analyzed from the sampled organs. Adp−/− mice showed impaired glucose tolerance and insulin resistance. Additionally, PPARα levels were decreased and plasma concentration of triglyceride, FFA and TNFα were increased. These data may indicate that insulin resistance in Adp−/− mice is likely caused by an increase in concentrations of TNFα and FFA via downregulation of PPARα. |
Databáze: | OpenAIRE |
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