Determinants of disability in multiple sclerosis at various disease stages: a multiparametric magnetic resonance study
| Autor: | Giancarlo Comi, Vittorio Martinelli, Marco Rovaris, Annalisa Pulizzi, Massimo Filippi, Maria Pia Sormani, E. Judica |
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| Přispěvatelé: | Pulizzi, A, Rovaris, M, Judica, E, Sormani, Mp, Martinelli, V, Comi, G, Filippi, M |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Time Factors Disease stages Cohort Studies Lesion Central nervous system disease White matter Disability Evaluation Multiple Sclerosis Relapsing-Remitting Arts and Humanities (miscellaneous) Fractional anisotropy medicine Humans Periaqueductal Gray Pathological Aged Aspartic Acid medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging Syndrome Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease Cross-Sectional Studies Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Anisotropy Female Neurology (clinical) Nervous System Diseases medicine.symptom Nuclear medicine business |
| Popis: | Objective: To investigate whether diffusion-tensor magnetic resonance imaging and whole brain N-acetylaspartate (WBNAA) proton magnetic resonance spectroscopy can provide complementary pieces of information to achieve a better understanding of the factors associated with disability in multiple sclerosis (MS). Design: Cross-sectional survey. Setting: Referral hospital-based MS center. Patients: Ten healthy control subjects, 27 patients with a clinically isolated neurological syndrome, 21 patients with relapsing-remitting MS, and 29 patients with secondary progressive MS. Main Outcome Measures: Conventional and diffusion-tensor magnetic resonance imaging, as well as WBNAA proton magnetic resonance spectroscopy, of the brain was performed. T2-hyperintense lesion volumes were measured. The mean values of mean diffusivity (MD) and fractional anisotropy of T2-visible lesions were computed. Histograms of MD and fractional anisotropy values were produced for normal-appearing white matter and gray matter (GM). Results: Patients with a clinically isolated neurological syndrome had a significantly (P=.002) lower WBNAA concentration than control subjects. Patients with relapsing-remitting MS had significantly higher T2 lesion volume (P=.007), mean lesion MD (P=.003), normal-appearing white matter fractional anisotropy peak height (P=.03), and a lower WBNAA concentration (P |
| Databáze: | OpenAIRE |
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