Monitoring and detection of cytomegalovirus in liver transplant recipients
| Autor: | A. Milan, Sandra Cecília Botelho Costa, Paula Durante Andrade, A.C. Guardia, Elaine Cristina de Ataide, Sandra Helena Alves Bonon, Raquel Silveira Bello Stucchi, Ilka de Fátima Santana Ferreira Boin, Célia Regina Pavan, A.M. Sampaio |
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| Rok vydání: | 2011 |
| Předmět: |
Human cytomegalovirus
Male medicine.medical_specialty Time Factors Opportunistic infection medicine.medical_treatment Congenital cytomegalovirus infection Cytomegalovirus Liver transplantation Gastroenterology Polymerase Chain Reaction Organ transplantation Betaherpesvirinae Predictive Value of Tests Internal medicine medicine Humans Antigens Viral Transplantation biology business.industry medicine.disease biology.organism_classification Surgery Liver Transplantation Early Diagnosis Treatment Outcome Cytomegalovirus Infections DNA Viral Female business Complication Biomarkers Brazil Immunosuppressive Agents |
| Zdroj: | Transplantation proceedings. 43(4) |
| ISSN: | 1873-2623 |
| Popis: | Cytomegalovirus (CMV) is a β-herpesvirus. CMV infections are a common complication contributing to morbidity and mortality after liver transplantation. Among organ transplant recipients, CMV can reactivate from latency during the first 6 months. This prospective study performed from February 2008 to December 2009 examined liver transplant recipients during the first 6 months. Two methods were performed to detect CMV infections: antigenemia (AGM) and nested (PCR). Ninety-four patients, including 72 men (76.6%) and 22 women (23.4%) underwent liver transplantation during this period. We analyzed 575 samples including 465 for AGM and PCR. Forty-three (9.25%) showed positive AGM as detected 2 to 179 days posttransplantation with a mean of 50 days and a median of 35 days, and 93/465 (20%) showed positive PCR at 0 to 186 days posttransplantation with a mean of 31 days and a median of 38 days. Among the 43 antigenemia patients, 38 samples were positive for up to 5 cells 18 of which were PCR-positive. Five samples were positive with more than 5 cells, including 3 that were PCR-positive. Only 4.51% had AGM and were PCR-positive in the same sample. Despite only 9.25% (43/465) showing AGM, the current study suggested the utility of routine monitoring to detect early CMV infection among liver transplantation patients seeking to reduce morbidity and mortality. |
| Databáze: | OpenAIRE |
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