Antiproliferative Amaryllidaceae Alkaloids Isolated from the Bulbs of Sprekelia formosissima and Hymenocallis × festalis
| Autor: | Krisztina Wolfard, Joseph Molnár, Imre Máthé, Derek Sharples, Peter Forgo, Annamária Molnár, Judit Hohmann, Theresia Thalhammer |
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| Rok vydání: | 2002 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Dioxoles Pharmacognosy Nucleic Acid Denaturation Hymenocallis Analytical Chemistry Magnoliopsida Mice chemistry.chemical_compound Alkaloids RNA Transfer Drug Discovery Tumor Cells Cultured Animals Leukemia L5178 Amaryllidaceae Alkaloids P-glycoprotein Pharmacology Aniline Compounds Molecular Structure Plant Stems biology Alkaloid Organic Chemistry DNA Amaryllidaceae biology.organism_classification Lycorine Antineoplastic Agents Phytogenic Drug Resistance Multiple Phenanthridines Multiple drug resistance Verapamil Complementary and alternative medicine Biochemistry chemistry biology.protein Molecular Medicine |
| Zdroj: | Planta Medica. 68:454-457 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2002-32068 |
| Popis: | Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lymphoma cells. Lycorine, haemanthidine and haemanthamine displayed pronounced cell growth inhibitory activities against both drug-sensitive and drug-resistant cell lines, but did not significantly inhibit mdr-1 p-glycoprotein. Thus, the tested alkaloids are apparently not substrates for the mdr efflux pump. Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA. |
| Databáze: | OpenAIRE |
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