CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression
| Autor: | João Felipe Peres Rezer, Leonardo Lanes da Silveira, Angela C F Marques, Matheus H Jantsch, Jean L.G. da Silva, Daniela B.R. Leal, Alexandre V Schwarzbold, Maria Rosa Chitolina Schetinger, Daniela F. Passos, Enzo Disconzi, João M. Bremm |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry T cell CD4-CD8 Ratio medicine.disease Virology Comorbidity 03 medical and health sciences 0302 clinical medicine Infectious Diseases medicine.anatomical_structure Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine 030211 gastroenterology & hepatology 030212 general & internal medicine Viral suppression business Viral load Neurocognitive CD8 |
| Zdroj: | Journal of Medical Virology. 92:3254-3264 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | The progression of the human immunodeficiency virus (HIV) infection to acquired immunodeficiency syndrome (AIDS) can be efficiently interrupted by antiretroviral therapy (ART). However, even successfully treated HIV-infected individuals are prone to develop non-AIDS-related diseases that affect the metabolism and several organs and systems. Biomarkers that predict the occurrence of comorbidities may help develop preventive measures. Current research shows that CD4+ T cell counts and viral load do not predict the development of non-AIDS-related diseases. The CD4/CD8 ratio has been indicated as a suitable marker of persistent immune dysfunction and the occurrence of non-AIDS-related events in treated HIV-positive patients. In this study, we explored the relationship between CD4/CD8 ratios, comorbidities, and aging in ART-treated HIV patients on viral suppression. We collected and evaluated data from 352 HIV-positive adults who were virologically suppressed ( |
| Databáze: | OpenAIRE |
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