Comparison of intravenous magnesium sulphate and lidocaine for attenuation of cardiovascular response to laryngoscopy and endotracheal intubation in elective surgical patients at Zewditu Memorial Hospital Addis Ababa, Ethiopia

Autor: Mulualem Sitote, Fetene Seyoum, Metages Hune, Alekaw Sema, Suliman Jemal, Abebaw Misganaw, Eyayalem Melese, Dagim Bimrew
Rok vydání: 2021
Předmět:
Male
Lidocaine
Haemodynamic response
medicine.medical_treatment
Hemodynamics
Blood Pressure
Vascular Medicine
Mathematical and Statistical Techniques
0302 clinical medicine
Heart Rate
030202 anesthesiology
Tachycardia
Medicine and Health Sciences
Intubation
Magnesium
Prospective Studies
Anesthetics
Local
Multidisciplinary
medicine.diagnostic_test
Sulfates
Statistics
Hematology
Middle Aged
Chemistry
Elective Surgical Procedures
Anesthesia
Physical Sciences
Hypertension
Medicine
Administration
Intravenous
Female
Anatomy
Larynx
Research Article
Chemical Elements
medicine.drug
Adult
Adolescent
Science
Laryngoscopy
Cardiology
Diastole
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Throat
Magnesium Sulfate
Young Adult
03 medical and health sciences
Heart rate
Intubation
Intratracheal
medicine
Humans
Arterial Pressure
Statistical Methods
Analysis of Variance
business.industry
Chemical Compounds
Biology and Life Sciences
030208 emergency & critical care medicine
Blood pressure
Salts
Ethiopia
business
Neck
Mathematics
Zdroj: PLoS ONE, Vol 16, Iss 6, p e0252465 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Background Laryngoscopy and endotracheal intubation are essential components of general anesthesia. But it is always associated with side effects called reflex cardiovascular responses. Many methods have been identified to attenuate these responses like intravenous lidocaine, deep inhalational anesthesia, vasodilators, intravenous magnesium sulphate even though therapeutic superiority remains understudied. Methods An institutional-based cohort study on 112 adult patients aged between 18–60 years was applied. 37 patients in the non-exposed group (Group N), 37 in the lidocaine group (Group L), and 38 in magnesium sulphate (Group M) were included. The hemodynamic parameters like heart rate, systolic, diastolic and mean arterial blood pressure at various time points up to 7 minutes post-intubation were recorded and the effect of both drugs to reduce hemodynamic responses was compared. Parametric data were analyzed using ANOVA and nonparametric data using the Kuruska-Wallis H rank test. P-value < 0.05 considered statistically significant. Results In all three groups, there was a statistically significant rise in heart rate and blood pressure from baseline. There was a statistically significant difference in mean heart rate throughout study minutes among the groups (pth minutes in DBP. There was significantly lower blood pressure in group M compared to both groups. Conclusion In conclusion, prophylactic administration of magnesium sulphate and lidocaine was effective in attenuating hemodynamic responses to the stress effect of laryngoscopy and intubation. But based on our finding prophylaxis of magnesium sulphate is associated with a more favorable hemodynamic response.
Databáze: OpenAIRE
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