The Melatonin Receptors in Rat Ontogenesis
| Autor: | J Vanĕcek |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Aging endocrine system medicine.medical_specialty Pituitary gland Endocrinology Diabetes and Metabolism Receptors Melatonin Biology Melatonin receptor Melatonin Cellular and Molecular Neuroscience Endocrinology Anterior pituitary Pituitary Gland Anterior Internal medicine medicine Animals Neurotransmitter metabolism Receptor Endocrine and Autonomic Systems Cell Membrane Median Eminence Rats Inbred Strains Rats Receptors Neurotransmitter medicine.anatomical_structure Median eminence Melatonin binding hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroendocrinology. 48:201-203 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000125008 |
| Popis: | The development of melatonin receptors in the rat pituitary and median eminence was studied using [125I]melatonin as a ligand. The specific binding was detected in pituitaries of 20-day-old fetuses already. The affinity of the receptor to the ligand (Kd) was in the range 63-133 pM and it did not change significantly during development. The pituitary concentration of [125I]melatonin binding sites was highest in 20-day-old fetuses (Bmax = 31 fmol/mg protein) and then it gradually decreased in the course of postnatal development, until it reached 10% of that value in 29-day-old males. In contrast, the concentration of melatonin receptors in median eminence did not change markedly in the course of development and it was about 15 fmol/mg protein. The marked decrease in the number of the pituitary receptors may be the cause of the reported developmental loss of the melatonin inhibitory effect on LHRH-induced LH release from anterior pituitary. |
| Databáze: | OpenAIRE |
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