Free fragments of gamma chain in the urine. A possible source of confusion with gamma heavy-chain disease
| Autor: | Elaine Z. Charles, Andres J. Valdes |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Chemistry Urinary system Immunoglobulin gamma-Chains General Medicine Urine Immunoelectrophoresis medicine.disease Immunoglobulin light chain Molecular biology Heavy chain disease Diagnosis Differential Immunoglobulin Fragments medicine Humans medicine.symptom Multiple Myeloma Confusion Heavy Chain Disease |
| Zdroj: | American journal of clinical pathology. 101(4) |
| ISSN: | 0002-9173 |
| Popis: | With currently used microconcentrators, high-resolution electrophoresis, and immunofixation electrophoresis, relatively homogeneous free fragments of gamma chain (FFGC) unaccompanied by light chains, which cannot be found in the serum, may be discovered in the alpha-2 region during routine examination of the urine. The urinary alpha-migrating FFGC is of no apparent clinical significance and should not be confused with the antigenically related FFGCs of gamma heavy-chain disease. In gamma heavy-chain disease, the FFGCs are often demonstrable in the urine, but are always present in the serum and migrate in the beta-gamma region. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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