Neonatal status epilepticus due to lamination disorder without significant cell death
| Autor: | Pierre Gressens, Louise Devisme, Hélène Ansart-Franquet, Marie-Eve Renard-Edun, Marie-Dominique Lamblin, Claude-Alain Maurage, Stéphane Auvin, Nadine Kacet, G. Soto-Ares |
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| Rok vydání: | 2011 |
| Předmět: |
Programmed cell death
Pathology medicine.medical_specialty Status epilepticus Fatal Outcome Status Epilepticus Developmental Neuroscience Refractory Animals Humans Medicine Cell Death medicine.diagnostic_test business.industry Infant Newborn Brain Magnetic resonance imaging General Medicine Human brain Magnetic Resonance Imaging medicine.anatomical_structure Cerebral cortex Pediatrics Perinatology and Child Health Gestation Female Neurology (clinical) Abnormality medicine.symptom business |
| Zdroj: | Brain and Development. 33:339-344 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/j.braindev.2010.04.005 |
| Popis: | Background: Malformations of the cerebral cortex may be associated with severe epilepsy and status epilepticus. It has been shown that status epilepticus models induce excitotoxic cell death. In humans, very few data are available. Case and results: We report a case of a multifocal disorder of the lamination diagnosed in a neonate, borne at 30 weeks’ gestation, who died from a refractory status epilepticus at two months and half. This abnormality was not detected by repeated MRI studies. Only microscopic investigations permitted to identify this disorder of the lamination. We found also little cell death or cell loss. Discussion: Our report highlights the possible false negative results of MRI in a newborn. We can also discuss that immature human brain maybe less sensitive to neuronal injury than mature as described in animal models. |
| Databáze: | OpenAIRE |
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