Endogenous CCK in the Control of Gastric Emptying of Glucose and Maltose
| Autor: | Timothy H. Moran, Douglas G Field, Timothy S. Carrigan, Susan B. Knipp, Gary J. Schwartz |
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| Rok vydání: | 1997 |
| Předmět: |
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medicine.medical_specialty Physiology Endogeny Devazepide Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Hormone Antagonists Endocrinology Internal medicine medicine Animals Maltose Cholecystokinin Osmole Benzodiazepinones Dose-Response Relationship Drug Gastric emptying Osmotic concentration Osmolar Concentration digestive oral and skin physiology Antagonist Macaca mulatta Glucose Gastric Emptying chemistry |
| Zdroj: | Peptides. 18:547-550 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(97)00062-4 |
| Popis: | Moran, T. H., D. G. Field, S. Knipp, T. S. Carrigan and G. J. Schwartz. Endogenous CCK in the control of gastric emptying of glucose and maltose. Peptides 18(4) 547–550, 1997.—A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys was assessed. Intragastric administration of a dose range (10–100 μ g/kg) of the CCK A receptor antagonist devazepide produced a dose dependent acceleration of the emptying of 100 ml 300 mOsm test meals of glucose and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 μ g/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl. These data expand the demonstrated role of endogenous CCK in the slowing of gastric emptying of nutrients in rhesus monkeys to carbohydrates and suggest that previous negative results were due to the hyperosmotic nature of the glucose solutions. |
| Databáze: | OpenAIRE |
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