Proteinuria in rats in relation to age-dependent renal changes
| Autor: | Jeannette M. Alt, H. Stolte, Friedrich Deerberg, Hansjoachim Hackbarth |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Aging Urinary system Renal function Kidney Excretion Sex Factors Internal medicine medicine Animals Proteinuria General Veterinary business.industry Body Weight Albumin medicine.disease Blood proteins Rats Endocrinology Renal physiology Animal Science and Zoology medicine.symptom business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Laboratory animals. 14(2) |
| ISSN: | 0023-6772 |
| Popis: | A variety of sex-dependent urinary proteins of low molecular weight, absent in females and in castrated males, can be identified in male rats by disc electrophoresis. In the urine of male rats of age 5·5 months, albumin comprises only 1-2% of the total protein. Albumin excretion increases greatly with age and associated kidney disease. Total protein excretion, however, stays the same or even decreases slightly as the rat ages, due to a loss of low molecular weight, sex-dependent, proteins. These are virtually absent in senescent rats (38 months of age), although total protein excretion rises tenfold in these animals due to high molecular weight plasma proteins passing into the urine; the glomerular filtration rate decreases to 70% of the value measured at 5·5 months of age. |
| Databáze: | OpenAIRE |
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