Transient impairment of recognition memory following ibotenic-acid lesions of the basal forebrain in macaques
| Autor: | Gary L. Wenk, Susan J. Mitchell, Donald L. Price, Mahlon R. DeLong, John Patrick Aggleton, Thomas G. Aigner, K. D. Pettigrew, Robert G. Struble, Mortimer Mishkin |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Physostigmine Central nervous system Scopolamine Biology Nucleus basalis Choline O-Acetyltransferase Lesion chemistry.chemical_compound Cognition Prosencephalon Substantia Innominata Memory Parasympathetic Nervous System Internal medicine medicine Animals Memory disorder Ibotenic Acid Recognition memory Cerebral Cortex Basal forebrain General Neuroscience medicine.disease Macaca fascicularis Endocrinology medicine.anatomical_structure chemistry Acetylcholinesterase Visual Perception Cholinergic medicine.symptom Neuroscience Ibotenic acid |
| Zdroj: | Experimental brain research. 86(1) |
| ISSN: | 0014-4819 |
| Popis: | To assess the contributions of the basal forebrain cholinergic nuclei to visual recognition memory in macaques, we compared the effects of lesions of (a) the nucleus basalis of Meynert, (b) the medial septal and diagonal band nuclei, and (c) all nuclei combined on performance of delayed nonmatching-to-sample with trial-unique stimuli. Whereas monkeys with the separate lesions did not differ from each other or from normal control animals, those with combined lesions showed a significant impairment. With time and extended practice, however, the performance of the animals with combined lesions recovered to normal levels. During the recovery period, these monkeys showed an initially increased sensitivity to scopolamine that later dissipated, at which time they also failed to show the improvement that follows physostigmine administration in normal animals. Postmortem assessment of cortical choline acetyltransferase activity revealed that only the group with combined lesions had significant depletion of this enzyme. The results suggest that (1) the basal forebrain cholinergic system participates in mnemonic processes in primates and that (2) extensive damage to this system is necessary before impairments in recognition memory, even transient ones, can be observed. |
| Databáze: | OpenAIRE |
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