Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea
| Autor: | Chunlin Zhuang, Peng Sun, Ming-Ping La, Wen Zhang, Baoshu Liu, Hua Tang, Yang-Hua Yi, Cui Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
China
Antifungal Agents Stereochemistry gorgonian briarane diterpenoids biological activity structure elucidation Dichotella gemmacea Pharmaceutical Science medicine.disease_cause 01 natural sciences Article chemistry.chemical_compound Cell Line Tumor Drug Discovery medicine Escherichia coli Bioassay Animals Humans Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Bacillus megaterium biology 010405 organic chemistry Chemistry Biological activity biology.organism_classification Anthozoa 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Gorgonian lcsh:Biology (General) A549 Cells Growth inhibition Diterpenes Antibacterial activity Bacteria |
| Zdroj: | Marine Drugs, Vol 14, Iss 11, p 201 (2016) Marine Drugs Marine Drugs; Volume 14; Issue 11; Pages: 201 |
| ISSN: | 1660-3397 |
| Popis: | Seven new briarane diterpenoids, gemmacolides AZ–BF (1–7), were isolated together with eight known analogues (8–15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli. |
| Databáze: | OpenAIRE |
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