Comparison of salmeterol/fluticasone propionate (FP) combination with FP+sustained release theophylline in moderate asthma patients
Autor: | Kyousuke Ishihara, Hisamichi Aizawa, Mitsuyoshi Nakashima, Hiroyuki Taniguchi, Yasuyuki Sano, Ken Ohta, Mitsuru Adachi |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Vital capacity Fluticasone propionate Placebo Drug Administration Schedule FEV1/FVC ratio Japan Theophylline Forced Expiratory Volume Administration Inhalation medicine Humans Albuterol Salmeterol Salmeterol Xinafoate Aged Asthma Fluticasone Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Bronchodilator Agents Androstadienes Treatment Outcome Anesthesia Drug Therapy Combination Female business medicine.drug |
Zdroj: | Respiratory Medicine. 102(7):1055-1064 |
ISSN: | 0954-6111 |
DOI: | 10.1016/j.rmed.2008.01.021 |
Popis: | Summary Objectives To compare the efficacy and safety of the salmeterol/fluticasone propionate combination product with concurrent sustained release theophylline plus fluticasone propionate in adult Japanese patients with persistent asthma. Design Multicentre, randomised, double-blind, double-dummy, parallel-group study. Patients and interventions Three hundred and eighty-three asthmatic patients receiving sustained release theophylline 200–400mg/day entered the study and were randomised to receive either salmeterol/fluticasone propionate combination (SFC) 50μg/250μg+1 placebo tablet, fluticasone propionate 250μg+1 sustained release theophylline 200mg (SR-T+FP), twice daily for 8 weeks. Results The adjusted mean change morning peak expiratory flow (PEF) over 8 weeks was 29.8L/min in the SFC group and 16.3L/min in the SR-T+FP group, with a treatment difference of 13.4L/min ( p =0.0004). SFC improved evening PEF, FEV 1 , V ˙ 50 and V ˙ 25 at the completion of treatment to a greater extent than SR-T+FP (all p p =0.0286) and rescue free (ns) than those on SR-T+FP. There was not a statistically significant difference between treatments in symptom scores. Both treatments were well tolerated. Conclusions The finding that SFC was associated with greater improvements in lung function than SR-T+FP, a commonly employed treatment for asthmatic patients in Japan, suggests that SFC should be the preferred therapeutic option in these patients. |
Databáze: | OpenAIRE |
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